INNOVATIONS

NANOBIOCOM focuses on the development of an intelligent material with the following challenges:

The bioactivity of the composite, which is rendered by the bioactive components (nanoparticles, carbon nanotubes, polymers) in the composite and/or by external stimulation (BMP’s, Electrical Fields, biofunctionalitation) will active osteoprogenitor cells and gens, and consequently promote the tissue growth adjacent to the implant.

Mechanical and structural properties of the scaffold equal to a healthy bone synchronous with new bone formation. By the incorporation of nanoparticles as carbon nanotubes and nanohidroxiapatite into the composite are expected to be highly suitable reinforcement for the implants of the load bearing structures of our body such as bone and cartilage.

The size and shape of biodegradable implants. We are going made large segments of implants required for reconstructing big defects capable of supplying similar physical properties and behavior of healthy bone to be replaced, in contrast with the small implants that are made at present.

Understanding the genetic programming of bone regeneration. To realize the potential for novel “intelligent” composite materials to serve as scaffolds for bone regeneration requires that the innate programming mechanisms involved in bone development and repair are effectively harnessed

To promote new bone formation in order to reduce the time of bone healing and decrease the vascular insult of the implant to the bone and cause less-stress shielding.

 

The main output of NANOBIOCOM project will be:

• An appropriate cell bioactive system to initiate repair and regeneration of bone.
• Intelligent composite for 3D scaffold, which will be able to support physiological loading until sufficient tissue regeneration occurs and will be possible manufacture large segments.
• A comprehensive gene expression profiles of the temporal regulation of gene expression during bone development.